DrugSense is a software tool able to predict the drug(s) to which the patient’s tumour will be most sensitive to by analysing the transcriptional profile of the tumour sample. The input of DrugSense is the transcriptional profile of the tumour, while the output is a list of drugs ranked according to their predicted potency in the patient, with the most potent at the top. DrugSense is based on a data-driven model derived from large publicly available collections of gene expression profiles of 1,000 cancer cell lines, and of dose-response curves of these cell lines to over 400 drugs and research compounds.